Figure 3.

Relationship between the actual value and the measured value of MRD in seven mixing experiments in which various amounts of DNA obtained at diagnosis from a patient with leukemia were mixed with up to 25 μg of DNA from a healthy individual to produce various levels of MRD. The open symbol indicates the one mixture that gave a negative result. The leukemic DNA from this patient was somewhat degraded, with only 6% of rearrangements being intact, and the MRD value shown corresponds to half an intact rearrangement being present in the 25 μg of DNA assayed.