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Quantitative analyses of the pathological changes. Fibrotic area in Masson’s trichrome (A), positive staining of α-smooth muscle actin (B), and F4/80 (C) was quantified (n = 5 in each group). *P < 0.05 wild type (Wt) versus transgenic (Tg) mice, #P < 0.05 versus adenine group.