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. 2009 Apr;174(4):1241–1251. doi: 10.2353/ajpath.2009.080814

Figure 1.

Figure 1

Immunohistochemical localization of pPERK, peIF2α, and pIRE1α in AD hippocampus. A: pPERK is detected by immunohistochemistry in pyramidal neurons in the hippocampus. In this case a part of the subiculum of an AD case is shown. The inset shows the cellular localization of pPERK, which is present in granules that can be defined as GVD. B: peIF2α immunohistochemistry on the same AD case and area as shown in A. peIF2α can also be detected in GVD granules (inset). C: pIRE1α can also be detected in pyramidal neurons in the hippocampus of AD cases (shown is subiculum). Similar granular structures were detected as observed with pPERK and peIF2α immunohistochemistry (inset). Scale bars: 200 μm (A–C); 20 μm (insets).