Figure 6.

Antibodies related to intestinal pathology correlate with signals from inflamed small intestines. Sera were screened for antibodies associated with small intestinal pathology. A: Levels of serum anti-transglutaminase 2 (TG2) autoantibodies (left) and anti-Gliadin (right) correlated with NF-κB bioluminescence from small intestines isolated from TCR⁺Id⁺Luc⁺ mice. B: Serum from a 15-week-old triply transgenic mouse with small intestinal light emissions gave an anti-endomycium staining pattern, [IgG (red), and smooth muscle cell nuclei (blue)]. C: Autoantibodies directed toward the small intestine of a BALB/c RAG2^−/− mouse. Left: serum from triply transgenic mouse (15 weeks old) with small intestinal signal and disease. Right: negative stain, serum from triply transgenic littermate (15 weeks) without small intestinal disease.