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. 2009 Apr;174(4):1390–1399. doi: 10.2353/ajpath.2009.080841

Figure 1.

Figure 1

A: Effect of β-structured ligands on the lipid raft protein flotillin-2. Administration of β-structured glycosphingolipids to DN32.D3NKT hybridoma cells in the presence of dendritic cells led to prominent flotillin-2 recruitment to raft fractions. The upper panel is a representative Western blot indicating the expression of flotillin-2. The lower panel is a representative dot blot indicating the expression of GM1. The numbers in both panels indicate the fraction number of samples obtained from a Nycodenz linear step gradient. B: Effect of treatment of Ob/Ob mice with β-glycosphingolipids for 6 weeks on glucose intolerance (P < 0.005 for B and D versus A), serum triglycerides (P < 0.005 for D versus A), intrahepatic fat accumulation, and liver weight (P < 0.005 for B, C, and D versus A). Experimental groups are specified in Table 1. Bars shows SD. *P < 0.05, **P < 0.001.