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. 2009 Apr;174(4):1564–1571. doi: 10.2353/ajpath.2009.080452

Figure 7.

Figure 7

Activation of MAP kinases by bFGF stimulation in wild-type (WT) and MT1-MMP KO cell lines. MT1-MMP KO and wild-type cell lines were serum-starved for 18 hours and treated with bFGF for 15, 30, or 60 minutes. The cell lysate was subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis with subsequent Western blot analysis with antibodies against phospho-ERK1/2, ERK1/2 (A), phospho-p38, p38 (B), or phospho-JNK and JNK (C). Comparison of the phosphorylation of MAP kinases on bFGF stimulation in MT1-MMP KO and KI cell lines. Cell lines were serum-starved for 18 hours and stimulated with bFGF for 15, 30, and 60 minutes. Cell lysates were subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis with subsequent Western blot analysis with antibodies against phospho-ERK1/2, ERK1/2 (D), phospho-p38, p38 (E), or phospho-JNK and JNK (F).