Figure 1.

Metabolic network related to anthranilate biosynthesis in E. coli. Arrows with dashed lines indicate more than one enzymatic reaction. Metabolite symbols: G6P, glucose 6-phosphate; F6P, fructose 6-phosphate; F1,6DP fructose 1,6 diphosphate; G3P, glyceraldehyde 3-phosphate; Ru5P, ribulose 5-phosphate; R5P, ribose 5-phosphate; X5P, xylulose 5-phosphate; S7P, sedoheptulose 7-phosphate; PYR, pyruvate; PEP, phosphoenolpyruvate; E4P, erythrose 4-phosphate; DAHP, 3-deoxy-D-arabino-heptulosonate 7-phosphate; CHA, chorismate; PPA, prephenate; ANT, anthranilate; L-Gln, L-glutamine; L-Glu, L-glutamate; L-Phe, L-phenylalanine; L-Tyr, L-tyrosine; L-Trp, L-tryptophan. Protein and gene symbols: IICB^Glc, glucose-specific integral membrane permease; TCA, tricarboxylic acid cycle; PTS, phosphotransferase transport system; tktA, transketolase; aroG^fbr, feedback inhibition resistant DAHP synthase; trpED, anthranilate synthase-phosphoribosyl transferase complex.