Table 5.

Correlation analysis of multiple gene expression profiles linked to metastasis biology or formation compared with each other

Quantized Variables Testing
Primary Signature	Test Signature	Ch-aquare P-value	Cramer's V	Fisher Exact P-value
VEGF profile	MetScore	0.0002	0.272	4.80E-04
VEGF profile	NKI 70-gene profile	0.0008	0.3126	3.60E-04
VEGF profile	Wound Response Profile	0.0001	0.3524	3.78E-06
VEGF profile	Intrinsic Subtype	< 0.0001	0.4223	4.29E-11
VEGF profile	hypoxia-signature	< 0.0001	0.6394	1.10E-15
VEGF profile	hypoxia-metagene (50:50)	< 0.0001	0.5722	8.29E-12
Intrinsic Subtype	MetScore	0.0054	0.2578	7.09E-04
Intrinsic Subtype	Hypoxia signature	< 0.0001	0.739	1.40E-20
Intrinsic Subtype	VEGF profile	< 0.0001	0.4223	4.29E-11
Intrinsic Subtype	NKI 70-gene profile	< 0.0001	0.4449	5.94E-06
Intrinsic Subtype	Wound Response Profile	< 0.0001	0.7389	1.56E-16
Intrinsic Subtype	Hypoxia metagene (50:50)	< 0.0001	0.5181	4.91E-09
Continuous Variables Testing
Primary Signature	Test Signature	ANOVA P-value
VEGF profile	BoneMeta 43 Up genes Average	< 0.0001
VEGF profile	Breast2Lung-Average	< 0.0001
VEGF profile	Snail1	< 0.0001
VEGF profile	Twist1	0.3
VEGF profile	11 stem cell signature-Average	0.0074
VEGF profile	6-Best-Glycolysis-Probes	< 0.0001
VEGF profile	Fibroblast-line-Avg	0.7
VEGF profile	HIF1A	0.0004
VEGF profile	hypoxia-metagene (50:50)	< 0.0001
Intrinsic Subtype	BoneMeta 43 Up genes Average	0.054
Intrinsic Subtype	Breast2Lung-Average	0.036
Intrinsic Subtype	Snail1	0.0002
Intrinsic Subtype	Twist1	0.2
Intrinsic Subtype	11 stem cell signature-Average	< 0.0001
Intrinsic Subtype	6-Best-Glycolysis-Probes	< 0.0001
Intrinsic Subtype	Fibroblast-line-Avg	0.012
Intrinsic Subtype	HIF1A	0.0033
Intrinsic Subtype	hypoxia-metagene (50:50)	< 0.0001