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. 2009 Apr 28;7(4):e1000097. doi: 10.1371/journal.pbio.1000097

Figure 5. PCA Loading Plot of the Relationship between Q Compound S100A9 or S100A8/A9 Binding Activity and aEAE Inhibition.

Figure 5

(A) Correlation between the binding strength to S100A9 of the Q compounds (Table S1) and their efficacy in inhibiting aEAE in vivo.

(B) Loading plot of the first two principal components (p[1] and p[2]) demonstrating the relationship between S100A9 and S100A8/A9 binding activity and aEAE inhibition. 1: mS100A8/A9 and mRAGE; 2: mS100A8/A9 and mLPS-Trap; 3: mS100A9 and ABR-224649; 4: mS100A9 and mLPS-Trap; 5: mS100A9 and mRAGE/hFc; 6: aEAE; 7: hS100A9 and rhTLR4/MD-2; and 8: hS100A9 and rhRAGE/Fc.