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. Author manuscript; available in PMC: 2010 May 11.
Published in final edited form as: J Biomech. 2009 Mar 3;42(7):873–877. doi: 10.1016/j.jbiomech.2009.01.024

Figure 1.

Figure 1

Axisymmetric finite element depiction of a chondrocyte, with distinct nuclear and cytoplasmic regions, undergoing unconfined compression. In its undeformed state (A), the cell is considered to be 10 μm tall and 12 μm wide, with a spherical nuclear inclusion of radius 2.5 μm. The lateral and axial deformations of both the cytoplasm and nucleus were measured in response a 25 nN load applied onto the cell (B). The linear elastic mechanical properties of the cytoplasm and nucleus were varied parametrically, and a cost function (δRMS) value was calculated for each case in comparison to known experimental data (Leipzig and Athanasiou, 2008). (ax = axial; lat = lateral)