Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Apr 17;15:793–800.

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Mutation analysis of CRYAA in Family 4. A: Pedigree of Family 4 shows the proband, which is indicated by the arrow. B: Direct sequencing of the PCR product encompasses exon 1 of CRYAA (5′→3′) of an unaffected individual (I-1). C: Direct sequencing of the PCR product encompassing exon 1 of CRYAA of an affected individual (II-1) shows a heterozygous C→T transition that replaced arginine by cysteine at amino acid 12 (R12C). The mutated sequence is shown in red. D: The slit-lamp photograph of individual I-2 shows a nuclear cataract. E: Alignment of residues 1–60 of human (8) αA-crystallin protein with rat (1), hamster (2), mouse (3), guinea pig (4), cow (5), sheep (6), pig (7) is shown. The R12 residue is marked in red.