Figure 7. MG132 antagonizes the toxicity of HHT and Rap on Tsc2^+/−Eμ-Myc lymphomas and interferes with their Dxr-associated synergism.

A. Cells were exposed to the indicated concentrations of HHT or Rap in the presence or absence of 10 µM MG132. Cell viability was determined 16 hrs later. The results are presented as the fraction of viable cells relative to vehicle (0.02% DMSO) treated samples with the standard deviation presented (n = 3). B. Lymphomas cells were treated with increasing concentrations and HHT and Dxr or Rap and Dxr at a fixed ratio in presence or absence of a fixed MG132 concentration (10 µM) for 16 hrs and the cell viability was determined. A CI value below 1 indicates a synergistic effect whereas a value above 1 represents antagonism. These experiments were performed three times with similar results.