Table 1.
Baseline Clinical Characteristics and Biomarker Levels for Women Initially Free of Hypertension with Normal Blood Pressure*
| Derivation cohort (n = 9427) | Validation cohort (n = 5395) | |
|---|---|---|
| Readily Clinically Available Predictors | ||
| Age, median (IQR), y | 51 (48 – 56) | 51 (48 – 56) |
| Systolic Blood Pressure, N (%), mm Hg | ||
| <110 | 2304 (24.4) | 1315 (24.4) |
| 110–119 | 4242 (45.0) | 2438 (45.2) |
| 120–129 | 2881 (30.6) | 1642 (30.4) |
| Diastolic Blood Pressure, N (%), mm Hg | ||
| <65 | 1398 (14.8) | 787 (14.6) |
| 65–74 | 4535 (48.1) | 2596 (48.1) |
| 75–84 | 3494 (37.1) | 2012 (37.3) |
| Body Mass Index, median (IQR), kg/m2 | 23.9 (21.9 – 26.6) | 23.9 (21.9 – 26.6) |
| Height, median (IQR), in | 65 (63 - 66) | 65 (63 - 66) |
| Weight, median (IQR), lb | 142 (130 – 160) | 143 (130 – 160) |
| Race, N (%) | ||
| White | 9077 (96.3) | 5174 (95.9) |
| Black | 104 (1.1) | 71 (1.3) |
| Hispanic | 90 (1.0) | 57 (1.1) |
| Asian | 123 (1.3) | 79 (1.5) |
| Other | 33 (0.4) | 14 (0.2) |
| Diabetes, N (%) | 102 (1.1) | 56 (1.0) |
| Smoking, N (%) | ||
| Never | 4932 (52.3) | 2790 (51.7) |
| Former | 3433 (36.4) | 1970 (36.5) |
| Current | 1062 (11.4) | 635 (11.8) |
| Family History of MI, N (%) | 1141 (12.1) | 603 (12.3) |
| Postmenopausal, N (%) | 4591 (48.7) | 2611 (48.5) |
| Any Alcohol Use, N (%) | 5491 (58.3) | 3188 (59.1) |
| Any Exercise, N (%) | 6245 (66.2) | 3539 (65.6) |
| Cholesterol Treatment, N (%) | 191 (2.0) | 93 (1.7) |
| Cholesterol Predictors | ||
| Total Cholesterol, median (IQR), mg\dL | 204 (180 – 231) | 204 (181 – 231) |
| HDL Cholesterol, median (IQR), mg\dL | 53.9 (45.1 – 64.2) | 53.7 (44.8 – 63.9) |
| LDL Cholesterol, median (IQR), mg\dL | 118.0 (97.6 – 140.7) | 118.7 (98.9 – 140.8) |
| Total/HDL Cholesterol, median (IQR) | 3.7 (3.1 – 4.6) | 3.8 (3.1 – 4.6) |
| Selected Additional Predictors | ||
| Estimated GFR, median (IQR), mL/min/1.73 m2 | 92.1 (80.1 – 105.6) | 92.1 (80.6 – 105.1) |
| hsCRP, median (IQR), mg\dL | 1.5 (0.6 – 3.4) | 1.6 (0.6 – 3.4) |
| Homocystine, median (IQR), μmol/L | 10.2 (8.5 – 12.6) | 10.4 (8.6 – 12.7) |
| Fibrinogen, median (IQR), mg\dL | 340.1 (299.7 – 387.9) | 342.4 (302.2 – 390.3) |
| SICAM-1, median (IQR), ng\mL | 333.5 (293.7 – 381.4) | 333.7 (294.7 – 382.9) |
| HbA1C, median (IQR), % | 5.0 (4.8 – 5.1) | 5.0 (4.8 – 5.1) |
| Apolipoprotein B-100, median (IQR), mg\dL | 95.4 (80.1 – 115.5) | 96.7 (80.7 – 116.4) |
| Apolipoprotein A-I, median (IQR), mg\dL | 150.4 (134.1 – 168.5) | 150.1 (133.3 – 168.8) |
| Lipoprotein (a), median (IQR), mg\dL | 10.0 (4.4 – 30.7) | 10.8 (4.6 – 31.6) |
| Servings of Grains per Day, median (IQR) | 3.3 (2.3 – 4.5) | 3.3 (2.3 – 4.6) |
*
Systolic Blood Pressure less than 130 mm Hg and diastolic blood pressure less than 85
IQR = inter-quartile range; HDL = high density lipoprotein; LDL = low density lipoprotein; GFR = glomerular filtration rate; hsCRP = high-sensitivity c-reactive protein; sICAM-1 = soluble inter-cellular adhesion molecule 1; HbA1C = hemoglobin A1C