Table 3.
Mutations and resulting folding times observed for geometry 2. The folding time for the wild type sequence is log10(t)=6.29±0.05. Also shown is the number of contacts disrupted (i.e., the number of interactions to which zero energy is ascribed) by each mutation. The folding time of the triple-point mutations marked with an * is estimated. Indeed, for the triple mutants 7:35:36 and 7:35:37 only 71% and 56% of the MC runs, respectively, reached the native state in the allowed number of MC steps.
| Mutation on bead(s) | No. of contacts disrupted | log10(t) |
|---|---|---|
| 8 | 3 | 6.62±0.04 |
| 28 | 4 | 6.63±0.04 |
| 6 | 3 | 6.68±0.06 |
| 10 | 2 | 6.72±0.05 |
| 19 | 4 | 6.76±0.05 |
| 21 | 2 | 6.76±0.05 |
| 34 | 3 | 6.78±0.05 |
| 9 | 3 | 6.83±0.05 |
| 34 | 1 | 6.78±0.05 |
| 35 | 2 | 6.82±0.04 |
| 7 | 4 | 6.84±0.05 |
| 37 | 3 | 6.84±0.05 |
| 36 | 4 | 7.10±0.05 |
| 37, 34 | 6 | 7.24±0.05 |
| 7, 35 | 7 | 7.60±0.04 |
| 36, 9 | 7 | 7.31±0.04 |
| 9, 37 | 6 | 7.33±0.04 |
| 9, 34 | 6 | 7.42±0.05 |
| 35, 37 | 7 | 7.46±0.04 |
| 36, 34 | 7 | 7.51±0.05 |
| 36, 37 | 7 | 7.52±0.04 |
| 36, 7 | 7 | 7.56±0.05 |
| 7, 34 | 7 | 7.73±0.05 |
| 7, 37 | 7 | 7.76±0.04 |
| 35, 36 | 7 | 7.80±0.04 |
| 36, 37, 34 | 10 | 8.00±0.04 |
| 7, 34, 36 | 10 | 8.45±0.04 |
| 7, 37, 34 | 10 | 8.58±0.04 |
| 7,35,36* | 11 | 9.46±0.06 |
| 7,35,37* | 10 | 9.61±0.05 |