Table 2.
Gene Name | Expression During Intestinal Differentiation | Expression in IM | Expression in GC | Functional Role in IM/GC |
---|---|---|---|---|
Muc1 | - | - - | - - - | Associated with gastric-type cell lineage |
Muc5AC | - | - - | - - - | Associated with gastric-type cell lineage |
Muc6 | - | - - | - - - | Associated with gastric-type cell lineage |
Sox2 | - | - - | - - - | Associated with gastric-type cell lineage |
P53 (wild-type) | - | - - | - - - | Induces apoptosis, inactivated by LOH |
P73 (wild type) | - | - - | - - - | TSG, induces apoptosis, belongs to p53 family |
RunX3 | - | - - | - - - | TSG silenced by hypermethylation; initiates Tgf-β-induced apoptosis, suppresses Vegf |
P21 (WAF1/CIP1) | - - - | Cell growth cycle inhibitor, inhibits cyclins D1 and E | ||
P27 (KIP1) | - - - | Cell growth cycle inhibitor, inhibits cyclins D1 and E | ||
Apc (mutation) | - | - - - | TSG: degrades β-catenin | |
Tgf-β-signalling pathway | - - - | TSG: Induces apoptosis | ||
P14 (ARF) | - - | - - - | TSG: regulates cell cycle, silenced by hypermethylation | |
P15 (INK4B) | - - | - - - | TSG: regulates cell cycle, silenced by hypermethylation | |
P16 (INK4A) | - - | - - - | Cell cycle regulator, induces G1-phase arrest, silenced by hypermethylation | |
P57 (KIP2) | - - | - - - | Inhibits cyclin-dependent kinases, silenced by hypermethylation | |
Dap-kinase | - - | - - - | Death-associated protein kinase involved in apoptosis, silenced by hypermethylation | |
hMLH1 | - | - - - | DNA mismatch repair gene inactivated by hypermethylation; causes MSI |
Key to Table 2:
-/- -/- - - refers to gradual decrease in expression/mutation
Minimal/reduced expression
Downregulated
Silenced