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. Author manuscript; available in PMC: 2009 Apr 22.
Published in final edited form as: Nat Med. 2008 Jun 1;14(6):667–675. doi: 10.1038/nm1775

Figure 1.

Figure 1

MBH leptin regulates adipose tissue lipogenesis. (a) Experimental protocol for catheter implantation and euglycemic clamp studies. To control for circulating glucose and insulin concentrations, rats underwent pancreatic basal-insulin clamp studies during a 6-h infusion of MBH leptin. (b) Protein expression of key lipogenic enzymes and the activation state of Atpcl, as assessed by a phosphospecific antibody, are reduced by MBH infusion of leptin. (c) 14C-palmitate incorporation is suppressed by MBH leptin in two different visceral WAT depots: the perirenal and epigonadal fat depots. *P < 0.05 versus MBH vehicle–treated group.