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. Author manuscript; available in PMC: 2009 Apr 22.
Published in final edited form as: Nat Med. 2008 Jun 1;14(6):667–675. doi: 10.1038/nm1775

Figure 5.

Figure 5

Control of WAT lipogenesis by MBH leptin requires intact autonomic innervation. (a) Lipogenic protein expression in denervated WAT of rats that were infused with either MBH vehicle or leptin as assessed by western blot analyses. MBH leptin failed to suppress lipogenic protein expression in denervated (Den) epidydimal fat pads, as compared to those in rats that had undergone sham surgery. (b) Hsl activation after MBH vehicle and leptin infusions in sham and denervated WAT. (c) MBH leptin did not affect Ampk activation in the sham group, whereas Ampk phosphorylation was upregulated in the denervated fat pads. Neither Creb phosphorylation nor Erk phosphorylation were affected by MBH leptin or by denervation. *P < 0.05, **P < 0.01.