Figure 1.

Localization of CD31, α-SMA, and periostin in normal and diseased pancreatic tissues: Immunohistochemical analysis was carried out using consecutive tissue sections of the normal pancreas. Sections were probed with antibodies against CD31 (A; original magnification, x200) for endothelial cells and against α-SMA (B) for smooth muscle cells and PSCs. Analysis of periostin expression in CP tissues (C–E; original magnification, x100): The PSCs in the periacinar spaces are marked by their periostin expression (C, arrows). Note that periostin-positive PSCs do not yet express α-SMA (D), and periostin has not yet been deposited in the periacinar spaces, where CD31-positive vessels are seen (E, arrows).