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. Author manuscript; available in PMC: 2009 Apr 22.
Published in final edited form as: Prog Brain Res. 2008;169:225–240. doi: 10.1016/S0079-6123(07)00013-1

Fig. 6.

Fig. 6

Activation of mGluR7 unmasks presynaptic MF-interneuron LTP. Application of the Group III mGluR agonist, L-AP4, triggers a chemical form of presynaptic mGluR7-dependent long-lasting depression. Subsequent delivery of a non-associative high-frequency stimulation (indicated by arrow) which in naïve tissue would induce LTD, now induces an LTP of MF–interneuron transmission. Synaptic events across the top of the dot plot are averaged paired pulse data taken from the time points indicated by the letters. Figure has been reproduced from Pelkey et al. (2005).