Table 2.
Novel functions represented by selected genes from 333 DEGs (differentially expressed genes) shared by five mouse–prion combinations
| Category | Gene symbola | Description | Entrez ID | Previous studiesb | Human orthologsc |
|---|---|---|---|---|---|
| Leukocyte extravasation | Csf1* | Colony-stimulating factor 1 (macrophage) | 12977 | CSF1 | |
| Prg1* | Proteoglycan 1, secretory granule | 19073 | SRGN | ||
| Selpl* | Selectin, platelet (p-selectin) ligand | 20345 | SELPLG | ||
| Cyba | Cytochrome b-245, alpha polypeptide | 13057 | R, X4 | CYBA | |
| Itgax | Integrin alpha X | 16411 | R, X4 | ITGAX | |
| Msn | Moesin | 17698 | R, X4 | MSN | |
| Androgen metabolism | Cyp7b1* | Cytochrome P450, family 7, subfamily b, polypeptide 1 | 13123 | CYP7B1 | |
| Hsd3b7* | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 101502 | HSD3B7 | ||
| Slco2b1* | Solute carrier organic anion transporter family, member 2b1 | 101488 | SLCO2B1 | ||
| Bzrp | Benzodiazepine receptor, peripheral | 12257 | X | TSPO | |
| Dbi | Diazepam-binding inhibitor | 13167 | S, Sk, Bo | DBI | |
| Iron homeostasis and heme metabolism | Cp* | Ceruloplasmin | 12870 | CP | |
| Hfe* | Hemochromatosis | 15216 | HFE | ||
| Slc39a14* | Solute carrier family 39 (zinc transporter), member 14 | 213053 | SLC39A14 | ||
| Ftl1 | Ferritin light chain 1 | 14325 | Sk | FTL | |
| Trf | Transferrin | 22041 | Sk, Bo | TF | |
| Demyelination, neurogenesis, axonal transport, ion channels | Kif5c* | Kinesin family member 5C | 16574 | KIF5C | |
| Lgi4* | Leucine-rich repeat LGI family, member 4 | 243914 | LGI4 | ||
| Nupr1* | Nuclear protein 1 | 56312 | NUPR1 | ||
| P2rx7* | Purinergic receptor P2X, ligand-gated ion channel, 7 | 18439 | P2RX7 | ||
| Scn1a* | Sodium channel, voltage-gated, type I, alpha | 20265 | SCN1A | ||
| Arachidonate/phospholipid metabolism and calcium signaling pathway | Alox5ap* | Arachidonate 5-lipoxygenase-activating protein | 11690 | ALOX5AP | |
| Cyp4f14* | Cytochrome P450, family 4, subfamily f, polypeptide 14 | 64385 | CYP4F2 | ||
| Ptgs1* | Prostaglandin-endoperoxide synthase 1 | 19224 | PTGS1 | ||
| Hpgd | Hydroxyprostaglandin dehydrogenase 15 (NAD) | 15446 | Bo, R | HPGD | |
| Plce1* | Phospholipase C, epsilon 1 | 74055 | PLCE1 | ||
| Adcy7* | Adenylate cyclase 7 | 11513 | ADCY7 | ||
| Hematopoiesis | Gmfg* | Glia maturation factor, gamma | 63986 | GMFG | |
| Inpp5d | Inositol polyphosphate-5-phosphatase D | 16331 | X | INPP5D | |
| Lcp1 | Lymphocyte cytosolic protein 1 | 18826 | X4 | LCP1 | |
| Lpxn | Leupaxin | 107321 | X | LPXN | |
| Nckap1l | NCK-associated protein 1 like | 105855 | X | NCKAP1L | |
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| Old gene symbolsd |
Updated gene symbol |
Description |
Entrez ID |
|
|
| Bzrp | Tspo | Translocator protein | 12257 | ||
| Prg1 | Srgn | Serglycin | 19073 | ||
| Selpl | Selplg | Selectin, platelet (p-selectin) ligand | 20345 |
aGenes with asterisk are unique DEGs to this study; genes in bold and italic show decreased expression in infected mouse brains.
bS (Sorensen et al, 2008); X (Xiang et al, 2007); Sk (Skinner et al, 2006); Br (Brown et al, 2005); Bo (Booth et al, 2004); R (Riemer et al, 2004); X4 (Xiang et al, 2004).
cOrthologous human gene symbols are current as of 28 August 2008.
dGene symbols have been updated in the EntrezGene database as of 28 August 2008.