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. 2009 Mar 17;5:248. doi: 10.1038/msb.2009.3

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Copyright © 2009, EMBO and Nature Publishing Group

This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. This licence does not permit commercial exploitation or the creation of derivative works without specific permission.

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The proteasome's role in telomere length regulation. Green nodes: TLM proteins, the mutants of which have elongated telomeres; blue nodes: TLM proteins, the mutants of which have short telomeres; yellow nodes: essential proteins that showed a short TLM phenotype in our new experimental data set. Beige nodes, TLM protein from the literature, the effect (short or long) of which on telomere length is not readily available; red nodes: protein products of essential genes (not on the TLM list); gray nodes: protein products of non-essential genes and not on the TLM list; purple node: the TELOMERE anchor node. (A) The mediator complex and the proteasome. Green frame: mediator complex components; red frame: proteasome subunits; blue frame: Est1/3 components of the telomerase. (B) DNA repair components and the proteasome. Green frame: Slx5(Hex3)–Slx8 complex; red frame: proteasome subunits; light blue frame: KEOPS complex; pink frame: MRX complex; yellow frame: ribonuclease H2 subunits. (C) Telomere Southern blot of the essential genes RGR1, PRE2, RPN6, RPN12 and RPT3 from the DAmP Yeast Library. DNA was digested with XhoI and probed with telomeric sequences and with unique genomic sequences used as markers (Askree et al, 2004). A red line marks the telomere size of the wild-type strain.