Table 5.
Treatment-emergent adverse events in early Parkinson’s disease (combined data from: Parkinson Study Group [1997]; Pogarell et al [2002]; Wong et al [2003])
| Adverse events | Pramipexole (n=388) | Placebo (n=235) |
|---|---|---|
| Asthenia | 14 | 12 |
| General edema | 5 | 3 |
| Malaise | 2 | 1 |
| Reaction unevaluable | 2 | 1 |
| Fever | 1 | 0 |
| Nausea | 28 | 18 |
| Constipation | 14 | 6 |
| Anorexia | 4 | 2 |
| Dysphagia | 2 | 0 |
| Peripheral edema | 5 | 4 |
| Decreased weight | 2 | 0 |
| Dizziness | 25 | 24 |
| Somnolence | 22 | 9 |
| Insomnia | 17 | 12 |
| Hallucinations | 9 | 3 |
| Confusion | 4 | 1 |
| Amnesia | 4 | 2 |
| Hypesthesia | 3 | 1 |
| Dystonia | 2 | 1 |
| Akathisia | 2 | 0 |
| Thinking abnormalities | 2 | 0 |
| Decreased libido | 1 | 0 |
| Myoclonus | 1 | 0 |
| Vision abnormalities | 3 | 0 |
| Impotence | 2 | 1 |