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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Ann Thorac Surg. 2008 Nov;86(5):1576–1583. doi: 10.1016/j.athoracsur.2008.06.076

Figure 1.

Figure 1

The absolute changes in plasma endothelin (panel A), interleukin-6 (panel B), and interleukin-10 (panel C) concentrations were computed at 0.5, 6, and 24 hours following infusion of increasing doses of the endothelin-A receptor (ET-AR) antagonist (0.1–2.0 mg/kg, black bars) or vehicle (0 mg/kg, white bars). At 24 hours post infusion, plasma endothelin levels were increased, except in the high dose ET-AR group. Plasma interleukin-6 levels were increased at 6 hours post infusion in all of the ET-AR antagonist groups. In contrast, interleukin-10 levels were reduced following infusion of the higher doses of the ET-AR antagonist, and this effect persisted at longer time points. (*p<0.05 vs. immediate post infusion time point, #p<0.05 vs. respective 0.5 hour time point)