Table 4.

Cognitive deficits in adult clinical hypothyroidism (AN: animal naming; BD: block design of WAIS-R; BEC-96: recall and visuoverbal recognition test; CC: cube copy; COWA: controlled oral word association; CVLT: California verbal learning test; CVMT: continuous visual memory test; DRS: Dementia rating scale (Mattis); DS: digit symbol subtest; FMT: Milner facial memory test; GNG,: Go-No go; HT: Hooper test; IPAL: Inglis paired associates learning; LMN: Luria m's and n's; MHV: Mill hill vocabulary scale; MMSE: minimental sate examination; MMMSE: modified Mini-Mental State Examination; OAS: object assembly subsets of WAIS-R; OR: oral reading; PASAT: paced auditory serial addition task; PM: Porteus mazes; ROCF: Rey-Osterrieth complex figure test; RPM: Raven progressive matrices test; SDMT: symbol digit modalities test; SRT: selective reminding test (Buschke); SVT: Shipley vocabulary test; TMT(A): Trail making part A; TMT(A,B): Trail making test parts A and B; VLT: verbal learning test ; WAIS: Wechsler adult intelligence scale; WAIS-R: Wechsler adult intelligence scale-revised ; WD: word discrimination; WFT: word fluency test; WMS: Wechsler memory scale).

Cognitive domain	Source	Altered	Treatment outcome	Measures
General intelligence	Capet et al. [43]	Yes	Improvement after 6 months	WAIS-R
	Mennemeier et al. [46]	Yes	Not generally affected	WAIS-R
	Haggerty et al. [45]	Yes	No change after 3 months	WAIS, DRS
	Crown [44]	Yes	Improvement after 8 months	RPM, MHV, SVT
Attention	Miller et al. [47]	No	No improvement	TMT(A)
	Capet et al. [43]	Yes	Improvement after 6 months	TMT(A), WMS,
	Mennemeier et al. [46]	No	Improvement after 7 months	PASAT
	Osterweil et al. [32]	Yes	Improvement after 8 months	TMT(A), SDMT
	Whybrow et al. [49]	Yes	No change after 10.5 months	TMT(A,B)
Memory	Miller et al. [47]	Yes	Improvement after 3 months	WMS, CVLT, RCFT
	Burmeister et al. [42]	Yes	Improvement	VLT
	Capet et al. [43]	Yes	Improvement after 6 months	WMS, BEC-96, WMS,
	Mennemeier et al. [46]	Yes	No change (but treatment may arrest further decline)	CVMT, FMT, RCFT, SRT, WMS
	Osterweil et al. [32]	Yes	Improvement	IPAL
	Haggerty et al. [45]	Yes	Not treated	WMS
Visuospatial abilities	Capet et al. [43]	Yes	Improvement after 6 months	TMT(A), WAIS-R, HT
	Mennemeier et al. [46]	Yes	Improvement	WAIS-R (BD, OAS)
	Osterweil et al. [32]	Yes	No improvement	CC
Language (expression)	Miller et al. [47]	No	No change	AN
	Capet et al. [43]	No	No improvement after 6 months	WFT
	Mennemeier et al. [46]	No	Not treated	WFT
	Osterweil et al. [32]	Yes	No improvement	WFT (Animals)
Language (reception)	Osterweil et al. [32]	No	Not treated	WD, OR
Executive functions	Miller et al. [47]	No	No change	TMT(B), COWA
	Mennemeier et al. [46]	No	Not treated	GNG, WFT, LMN
	Whybrow et al. [49]	Yes	No change	PM
Psychomotor speed	Burmeister et al. [42]	No	No change	WAIS-R
	Capet et al. [43]	Yes	Improvement after 6 months	WAIS-R, WFT, TMT(A, B)
Global cognition	Capet et al. [43]	Yes	Improvement after 6 months	MMSE
	Osterweil et al. [32]	Yes	No improvement	MMMSE
	Peabody et al. [48]	Yes	Progressive decline	MMSE