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. 2009 Mar 10;10(3):1000–1012. doi: 10.3390/ijms10031000

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© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 3. — Efficacy results of leuprorelin in SBMA patients. (A) The frequency of diffuse nuclear 1C2 staining (indicative of mutant AR) in the scrotal epithelial cells was significantly decreased after the 48-week administration of leuprorelin acetate. (B) Changes in the ALSFRS-R scores showed treatment duration-dependent improvements in the leuprorelin-treated groups. Scale bars = 50 μm. Data are expressed as means ± SEM. *p < 0.05; **p < 0.005; ***p < 0.001 with respect to Group D [36].