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. 2009 Mar 10;10(3):1000–1012. doi: 10.3390/ijms10031000

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© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 4. — Effects of leuprorelin acetate on nuclear accumulation of mutant AR. (A, B) The accumulation of mutant AR in neurons was remarkable both in the pontine base and in the spinal anterior horn of all the control, non-treated autopsied patients, but the number of 1C2-positive neurons was relatively small in the leuprorelin-treated patient. Scale bars=100 μm. (C) Mutant AR accumulation in biopsied scrotal skin epithelial cells was markedly reduced by leuprorelin. Scale bars=50 μm. Data are expressed as means±SD [36].