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. 2009 Mar 24;10(3):1369–1385. doi: 10.3390/ijms10031369

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© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 1. — Stability profiles depicting the different ways to increase the denaturation temperature (T_m). The solid thin line represents the stability curve for a hypothetical protein from an organism growing in moderate temperature. Proteins from hyperthermophiles can adapt to higher temperature by (i) shifting the curve up (solid thick line), (ii) shifting the curve to the right (dashed line), and (iii) flattening the curve (dotted line).