Table 3.
Parameters of survival, life span and tumorigenesis in PARP-1−/− and PARP-1+/+ mice.
| Parameters | PARP-1+/+ | PARP-1−/− |
|---|---|---|
| Number of mice | 103 | 73 |
| Mean life span (days, mean ± S.E.M.) | 678 ± 14.2 | 588 ± 14.4** |
| Median (days) | 686 | 597 |
| Mean life span of last 10% of survivors (days) | 919 ± 11.6 | 778 ± 14.3** |
| Maximum life span (days) | 983 | 822 |
| Aging rate, α (days−1) | 0.00771 (0.00760; 0.00782) | 0.00932 (0.00926: 0.00956)* |
| MRDT (days) | 89.88 (88.6; 91.22) | 74.36 (72.53; 74.89)* |
| Number of tumor-bearing mice | 79 (76.7%) | 53 (72.6%) |
| Number of malignant tumor-bearing mice | 48 (46.6%) | 49 (67.1%)*** |
| Mean life span of tumor-bearing mice (days, mean ± S.E.M.) | 706 ± 17.6 | 612 ± 19.2** |
| Total number of tumors | 120 | 82 |
| Total number of malignant tumors | 59 (49.2%) | 59 (72.0%)* |
α in Gompertz model: R = R 0 (exp)αt, where R 0 = mortality rate in the time of t = 0; 95% confidence limits are given in parentheses; MRDT, mortality rate doubling time.
The difference with the PARP-1+/+ is significant: *: P < .05; **: P < .002; ***: P < .001.