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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Mol Pharmacol. 2008 Aug 7;74(5):1429–1442. doi: 10.1124/mol.108.050609

Fig. 8.

Fig. 8

Role of PPARβ/δ in the modulation of gene expression by GW0742 or retinoic acid in mouse primary keratinocytes. Primary keratinocytes from wild-type (+/+) and PPARβ/δ-null (−/−) mice were treated for 8 (left) or 24 (right) h with either GW0742, atRA, or 9-cis RA at the indicated concentration. Quantitative real-time PCR was performed as described under Materials and Methods to examine the expression of mRNA encoding Angptl4 (A and B) or CYP26A1 (C and D) normalized to mRNA encoding GAPDH. Values are the average -fold change compared with control treatment and represent the mean ± S.E.M. Values with different letters are significantly different, P < 0.05, as determined by ANOVA and Bonferroni’s multiple comparison test.