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. Author manuscript; available in PMC: 2009 Apr 22.
Published in final edited form as: Nature. 2008 Aug 24;455(7215):930–935. doi: 10.1038/nature07261

Figure 3. Representative ALK copy number alterations in three neuroblastoma primary tumors.

Figure 3

Hybridization intensity reflecting copy number for all SNPs along chromosome 2p in three primary tumors from patients with sporadically occurring disease is shown, represented on a logarithmic scale. MYCN amplification is present in all tumors. a. Regional gain (trisomy) of chromosome 2p, including the ALK locus. b. Focal gain of the ALK locus. c. Focal amplification of the ALK locus. d and e. Complex rearrangement of the 2p locus, showing various focal amplicons, including MYCN and ALK.