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. Author manuscript; available in PMC: 2009 Apr 22.
Published in final edited form as: Nature. 2008 Aug 24;455(7215):930–935. doi: 10.1038/nature07261

Figure 4. ALK is highly expressed and the kinase is phosphorylated in neuroblastoma cell lines harboring activating mutations.

Figure 4

a. Relative ALK expression of neuroblastoma cell lines and fetal brain is shown and was determined using the 2-ΔΔCt method49. Statistical significance was determined by unpaired T-test. b. Immunoblots showing differential ALK expression in neuroblastoma cell lines with phosphorylation of the tyrosine 1604 codon restricted to cell lines with mutations (the wild-type lines NBEC1 and NB1771 show faint phosphostaining).