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Morphine sensitizes CGRP-release stimulated by acrolein. Release of CGRP from isolated hindpaw skin of mice was stimulated by 100 μM acrolein applied for 5 min (open symbols). The contralateral hindpaw skin of every animal was exposed to acrolein in the presence of 310 μM morphine (closed symbols) which sensitized the release of CGRP evoked by acrolein (n = 6). *p < 0.05
