Table 3.
Origin of previously described MSRV sequences
MSRV sequences | HERV-W source locus/loci | Number of nucleotide mismatches | |
env | no recombinations | recombinations | |
AF127227 (544 bp) | 3q23 | 1 (1.84/kb) | n.a. |
AF127228 (1932 bp) | Xq22.3 | 4 (2.07/kb) | n.a. |
AF127229 (2004 bp) | 3p12.3/18q21.32 | 94 (46.91/kb) | 3 (1.5/kb) |
AF123882 (2477 bp) | 15q21.3 | 5 (2.02/kb) | n.a. |
AF331500 (1629 bp) | Xq22.3/5p12 | 31 (19.03/kb) | 5 (3.07/kb) |
gag | |||
AF123881 (1511 bp) | 3q26.32 | 2 (1.32/kb) | n.a. |
Previously published MSRV sequences were assigned by BLAT searches to corresponding HERV-W elements in the human genome. The accession number and length (base pairs, bp) of published MSRV clones are provided in the left column. The best matching HERV-W locus or loci (in case of recombined sequences) are indicated in column 2, and the number of nucleotide mismatches between MSRV sequences and the best matching genomic HERV-W elements in column 3. Note that for the recombined sequences, the number of nucleotide mismatches after assuming recombinations is markedly reduced. The average number of nucleotide differences of the 6 analyzed MSRV sequences to their best matching genomic HERV-W locus/loci was 1.97/kb. n.a., not applicable