Table 1.
Scoring Method | Score categories | ECA | EMA | p-value |
C | Score 0–3 | 9 (64.3%) | 20 (83.3%) | .245a |
Score 4–12 | 5 (35.7%) | 4 (16.7%) | ||
Median (Range) | 2 (0–12) | 2 (0–12) | .152 | |
N | Score 0–3 | 3 (21.4%) | 17 (70.8%) | .006a |
Score 4–12 | 11 (78.6%) | 7 (29.2%) | ||
Median (Range) | 5 (2–12) | 2 (0–9) | <0.001b | |
Mean of C plus N | Score 0–3 | 4 (28.6%) | 21 (87.5%) | <0.001a |
Score 4–12 | 10 (71.4%) | 3 (12.5%) | ||
Median (Range) | 4.25 (2–12) | 2 (0–10.5) | <0.001b |
PS:
1. C: Method of scoring based on independent cytoplasmic staining alone, irrespective of nucleic staining.
2. N: Method of scoring based on independent nucleic staining alone, irrespective cytoplasmic staining.
3. Mean of C plus N: Method of scoring based on mean of cytoplasmic score plus nucleic score.
Note:
• The "a" is Chi-squared test with continuity correction or Fisher exact test, the "b" is Mann-Whitney U test using exact significant.
•Using score 4 points as a cutoff, the immunostains are defined "negative" for scores from 0 to 3, and "positive" for scores from 4 to 12 points.