Table 2.
Diagnostic performance of 4 scoring methods for measuring p16INK4a expression in correctively distinguishing 14 ECA from 24 EMA
| Scoring method | C | N | Mean of C plus N |
| Sensitivity | 35.7% | 78.6% | 71.4% |
| (95% CI) | (20.5%,50.9%) | (65.5%,91.6%) | (57.1%,85.8%) |
| Specificity | 83.3% | 70.8% | 87.5% |
| (95% CI) | (71.5%,95.2%) | (56.4%,85.3%) | (77.0%,98.0%) |
| PPV | 55.6% | 61.1% | 76.9% |
| (95% CI) | (39.8%,71.4%) | (45.6%,76.6%) | (63.5%,90.3%) |
| NPV | 69.0% | 85.0% | 84.0% |
| (95% CI) | (54.3%,83.7%) | (73.6%,96.4%) | (72.3%,95.7%) |
| Accuracy | 65.8% | 73.7% | 81.6% |
| (95% CI) | (50.7%,80.9%) | (59.7%,87.7%) | (69.3%,93.9%) |
PS:
1. C: Method of scoring based on independent cytoplasmic staining alone, irrespective of nucleic staining.
2. N: Method of scoring based on independent nucleic staining alone, irrespective cytoplasmic staining.
3. Mean of C plus N: Method of scoring based on mean of cytoplasmic score plus nucleic score.
Note:
Negative p16INK4a expression (score 0–3) tends to be EMA, whereas positive p16INK4a expression (scores 4–12) tends to be ECA.