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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Genes Brain Behav. 2009 Dec 17;8(3):283–289. doi: 10.1111/j.1601-183X.2008.00472.x

Figure 6. Schematic figure of the genealogical tree for C3H/He substrains.

Figure 6

The C3H/He progenitor strain arose in 1942 from original the C3H inbred strain which had been derived from a cross of a Bagg albino female with a DBA male. C3H/HeJ (HeJ) was introduced to The Jackson Laboratory in 1947 and C3HeB/Fe was developed in 1948 by transfer of fertilized ova of HeJ to C57BL/6. HeJ and C3H/HeOuJ (OuJ) substrains were separated in 1952. C3H/HeSnJ (SnJ) arose from C3H/He prior to the separation of HeJ. HeJ, OuJ and SnJ show an average of 20–30 SWD/hr while C3HeB/FeJ shows 4–5 SWD/hr. The present generation of each substrain was from JAX® Mice database (http://jaxmice.jax.org, Jan 2008). Black arrows represent events of mutations identified in HeJ in the previous study (Frankel et al., 2005). Sparkled and white arrows represent hypothetical events of mutations in OuJ and SnJ, respectively.