Skip to main content
. 2008 Jan;9(1):40–42.

Table 1.

ECG Entrance Criteria in Select Mega-Trials

Study Publication Year Duration of Symptoms Required Maximum Time to Onset Prior to Presentation EKG Change Requirements Other Requirements/Modifiers
ISIS - 1 (13) 1986 ----- 12 hr None MI suspected by MD
ISIS - 1 (14) 1988 ----- 24 hr None MI suspected by MD
GISSI - 2 (15) 1990 ----- 6 hr

  1. STE > 1mm in any limb lead

  2. STE > 2mm in any precordial lead
ISIS - 3 (16) 1992 ----- ----- None MD thought there was a “clear” indication for Fibrinolytics
GUSTO (17) 1993 20 min 6 hr

  1. STE > 0.1mV in 2 or more limb leads

  2. STE > 0.2mV in 2 or more contiguous precordial leads
GUSTO III (18) 1997 30 min 6 hr

  1. STE > 1mm in 2 or more limb leads

  2. STE > 2mm in precordial leads

  3. BBB
ASSENT - 2 (19) 1999 ----- 6 hr

  1. STE > 0.1mV in 2 or more limb leads

  2. STE > 0.2mV in 2 or more contiguous precordial leads

  3. LBBB
InTIME - II (20) 2000 30 min 6 hr

  1. STE > 0.1mV in any 2 contiguous limb leads

  2. STE > 0.2mV in any 2 contiguous precordial leads

  3. STE > 0.2mV in V4R

  4. STE > 0.2mV in 2 contiguous posterior leads

  5. New or presumed new LBBB
ASSENT - 3 (21) 2001 ----- 6hr

  1. STE > 0.1mV in 2 or more limb leads

  2. STE > 0.2mV in 2 or more contiguous precordial leads

  3. LBBB
GUSTO V (22) 2001 30 min 6hr “EKG criteria for STEMI or New LBBB” (with references to GUSTO, GUSTO III & ASSENT – 2)