. Author manuscript; available in PMC: 2009 Apr 23.

Published in final edited form as: Behav Neurosci. 2008 Dec;122(6):1248–1256. doi: 10.1037/a0013276

Table 1.

Effect of steady-state methadone (SSM) and generalized arousal (GA) on orexin and pro-opiomelanocortin (POMC) mRNA levels in the medial hypothalamus (MH), and plasma corticosterone (B) levels in male and female mice.

		SSM (0 mg/kg/day)		SSM (20 mg/kg/day)
		Non GA	GA	Non GA	GA
Orexin in the MH	Male	0.83 ± 0.07	0.83 ± 0.09	0.91 ± 0.08	0.84 ± 0.04
Orexin in the MH	Female	0.81 ± 0.14	0.94 ± 0.15	0.95 ± 0.10	0.91 ± 0.11
POMC in the MH	Male	3.1 ± 0.48	2.9 ± 0.56	2.9 ± 0.69	3.4 ± 0.64
POMC in the MH	Female	3.4 ± 0.86	2.8 ± 0.55	3.3 ± 0.53	3.1 ± 0.67
Plasma B	Male	14.3 ± 6.1	12.0 ± 3.1	15.2 ± 3.5	19.6 ± 3.5
Plasma B	Female	20.0 ± 8.1	12.1 ± 4.4	13.6 ± 3.6	12.0 ± 2.9