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Insulin resistance and hyperglycemia effects on brinolysis, coagulation, and platelet function
| Fibrinolysis | Coagulation | Platelets |
|---|---|---|
| Insulin resistance | ||
| ↑ PAI-1 | ↑ FVII, vWF, FVIII | ↓ Insulin-induced regulation |
| Hyperglycemia/AGE | ||
| ↑ PAI-1, altered balance PAI-1/tPA | ↑ TF, altered expressions FVII, FXII | Hyperreactivity, ↑ TX sensitivity/production |
