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. 2009 Apr 2;106(16):6772–6777. doi: 10.1073/pnas.0811331106

Fig. 4.

Fig. 4.

Behavioral responses to cocaine in MCH1R KO mice. (A) Cocaine-induced place preference in WT and MCH1R KO mice. CPP score: Time spent on the drug side minus time spent on the saline side during post conditioning (#, P < 0.05 vs. saline, ANOVA followed by Dunnett's test for multiple comparison; **, P < 0.01 vs. MCH1R KO mice, unpaired t test; n = 5–9). (B) Cocaine sensitization in WT and MCH1R KO mice (##, P = 0.0022 vs. day 3, paired t test; *, P < 0.05 vs. MCH1R KO mice, unpaired t test; n = 5–6). (C) Changes of phosphorylation of DARPP-32 (Thr 75) in WT and MCH1R KO mice after 5 days of saline or cocaine treatment. The data were normalized to saline treated WT group (a.u., arbitraty unit) (**, P < 0.01 vs. WT/coc mice, ANOVA followed by Bonferroni multiple comparison test; n = 4–6).