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. 2009 Apr 2;106(16):6772–6777. doi: 10.1073/pnas.0811331106

Fig. 5.

Fig. 5.

Effect of MCH system blockade on cocaine self-administration. (A) TPI 1361-17 (5–20 nmol i.c.v.) inhibition of cocaine self-administration under a FR1 measured by the number of cocaine infusions obtained (■) and the number of inactive responses (□) (*, P < 0.05; **, P < 0.01 vs. control, ANOVA followed by Dunnett's test for multiple comparison; n = 6–11). (B) Effect of TPI 1361-17 on cocaine self-administration under a PR schedule in rats (n = 6). Data are presented as the breakpoint (percentage baseline) (mean ± SEM). There was a significant TPI 1361-17 effect on breakpoint (#, P < 0.05, repeated measures ANOVA). Significant differences were determined by repeated measures 1-way ANOVA with Dunnette's post hoc comparison (*, P < 0.05 vs. control). (C) Cocaine self-administration on TPI 1361-17 administration into the NAcSh (1 μg/side) or into NAcCo (*, P < 0.05, unpaired t test; n = 6–7). R and NR indicate reinforced (■) and nonreinforced responses (□), respectively. Injection placements for NAcSh (○) and NAcCo (●) shown in Fig. S1.