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. 2009 Apr 2;106(16):6772–6777. doi: 10.1073/pnas.0811331106

Fig. 6.

Fig. 6.

Effect of MCH system blockade on cue-, cocaine-, and stress-induced reinstatements. (A) Cue-induced reinstatement: TPI 1361-17 inhibition of reinstatement induced by cocaine-associated cues, measured by the number of responses in the previously cocaine-paired hole (■) and in the inactive hole (□) (***, P < 0.001; n = 7–10). (B) Cocaine-induced reinstatement: TPI 1361-17 inhibition of reinstatement induced by priming injection of cocaine (10 mg/kg i.p.) (***, P < 0.001; n = 8). (C) Stress-induced reinstatement: TPI 1361-17 inhibition of reinstatement induced by priming injection of yohimbine (2.5 mg/kg i.p.) (**, P < 0.01; ***, P < 0.001; n = 7–8). Data expressed as mean ± SEM.