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. Author manuscript; available in PMC: 2010 Mar 17.
Published in final edited form as: Neuroscience. 2009 Mar 17;159(2):427–437. doi: 10.1016/j.neuroscience.2009.01.022

Fig. 4. Increase in spontaneous and induced seizures and shorten lifespan in DKO mice.

Fig. 4

(A) Frequency of handling-induced seizure increases with age in DKO mice (20-30 animals per group). (B) Latency in seconds for the development of PTZ-induced seizures (40 mg/kg body weight) as evaluated by loss of posture (10 mice per group). (C) Severity of kainic acid induced seizures (20mg/kg body weight) (10 mice per group). (D) Survival of WT (28 untreated, open circles) and DKO (31 untreated, closed circles) mice. Bars represent mean ± SEM. **P< 0.01.