Table 1.
Characteristics of studies reporting elevated apoptosis in the emphysematous lung
| Authors | Studied group | Control group | Apoptosis detection technique | Apoptotic cell type |
|---|---|---|---|---|
| Segura-Valdez et al 200022 | Smokers with emphysema | Smokers and nonsmokers without COPD | In situ end labeling | Mainly endothelial cells |
| Kasahara et al 200040 | Smokers with emphysema | Smokers and nonsmokers without emphysema | DNA fragmentation (TUNEL and LM-PCR) Single DNA detection (IHC) | Epithelial and endothelial cells |
| Yokohori et al 200411 | Subjects with emphysema (smoking state not specified) | Smokers and nonsmokers without emphysema | DNA fragmentation (TUNEL) | Epithelial cells (mainly type II alveolar cells) |
| Calabrese et al 200597 | Subjects with AAT-deficiency emphysema | Young subjects with unspecified smoking history | DNA fragmentation (TUNEL and agarose gel separation) | Alveolar wall cells |
| Imai et al 200510 | Ex-smokers (>6 months) with emphysema | Nonsmokers with unspecified lung functions | cleaved caspase-3 and PARP (Western blot) and DNA fragmentation (agarose gel separation) | Not mentionned |
Abbreviations: COPD, chronic obstructive pulmonary disease; IHC, immunohistochemistry; LM-PCR, ligation-mediated polymerase chain reaction; PARP, poly(ADP-ribose) polymerase; TUNEL, terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling.