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Collagen I staining. Immunohistochemical staining of bronchial biopsies for collagen I (immunoperoxidase, original magnification × 200) showed, a uniform red-brown-stained band beneath the epithelial layer in asthma (A left panel). In contrast to asthma, this is significantly less intense in COPD (p < 0.05, B right panel).
Abbreviation: COPD, chronic obstructive pulmonary disease.
