TABLE 1.
IC50 values of single-agent ABT-737, cisplatin, etoposide, or A-793844 against HNSCC cell lines
UM-22A, UM-22B, and 1483 cells were seeded in 48-well plates, grown overnight, and then treated for 48 h with varying doses of the indicated agents. Cell viabilities were assessed in triplicate via trypan blue exclusion assays, and IC50 values were calculated.
|
Cell Line |
IC50 |
|||
|---|---|---|---|---|
| ABT-737 | Cisplatin | Etoposide | A-793844 | |
| μM | ||||
| UM-22A | 53.6 | 14.5 | 34.5 | >100 |
| UM-22B | 36.2 | 23.6 | 34.3 | >100 |
| 1483 | 13.8 | 11.1 | 27.6 | 42.6 |