Fig. 5.

Effect of parthenolide on cell-cycle distribution in MV4-11 cells. MV4-11 cells were placed in serum-free medium to synchronize the cell cycle for 24 h. Cells were then treated with parthenolide (0, 3, and 10 μM) for 24 h. Cell-cycle distribution was determined by flow cytometry. A, representative sets of histogram for MV4-11 cells (A) and 3 μM (B) and 10 μM (C) parthenolide-treated cells. Percentages of cells in SubG₁, G₀/G₁, S, and G₂/M phase are shown as insets for each experiment.