Fig. 10.

Blockade of the discriminative stimulus effects of the training dose of carisoprodol (100 mg/kg p.o.). Top, percentage carisoprodol-lever responding. Bottom, rate of responding (r/s). The barbiturate antagonist bemegride fully antagonized the discriminative stimulus effects of carisoprodol, whereas the benzodiazepine antagonist flumazenil had little or no effect. Response rates were not significantly affected by either compound (n = 10 rats for bemegride and n = 9 for flumazenil, except where shown).