Fig. 4.

SFKs are involved in the secretion of CC and CXC chemokines in pancreatic acinar cells. Freshly isolated pancreatic acini were preincubated with either PP2 at 1 and 10 μM or PP3 at 1 μM for 30 min followed by stimulation with 1 μM SP for 45 min. The supernatant was used to measure MCP-1 (a), MIP-1α (b), and MIP-2 (c) levels by ELISA as described under Materials and Methods. The results are representative of three independent (n = 3) experiments. Results shown are the means + S.E. ^*, P ≤ 0.05 compared with control; +, P ≤ 0.05 compared with SP.