Fig. 7.

Involvement of SFKs in the mobilization of pancreatic neutrophils and chemokine in acute pancreatitis. Mice (n = 10 in each group) were given 10 hourly injections of caerulein (50 μg/kg i.p.). PP2 was administered in mice at doses of 0.5, 1, and 1.5 mg/kg i.p. 1 h before or at a dose of 1 mg/kg 1 h after the first caerulein injection. One hour after the last caerulein injection, mice were sacrificed by an intraperitoneal injection of a lethal dose of pentobarbitone, and pancreatic MPO (a), MCP-1 (b), MIP-1α (c), and MIP-2 (d) levels were measured as described under Materials and Methods. Results shown are the means + S.E. ^*, P ≤ 0.05 when caerulein-treated animals were compared with placebo-treated animals. +, P ≤ 0.05 when PP2-treated animals were compared with caerulein-treated animals.